![]() We have found that depression, previous head injury and family history of dementia may predict TGA recurrence.ĭementia Diffusion-weighted imaging Recurrent Risk factors Transient global amnesia. DWI lesions were observed in 24 patients and were located anywhere within the hippocampus.ĭWI lesions were not significantly associated with outcomes (recurrence, subjective memory impairment, dementia). Of 15 patients with confirmed recurrent TGA, two developed dementia and four subjective memory impairment. recurrent, 15.4% vs 46.7%, p = 0.01) and family history of dementia (isolated vs. It is often precipitated by particularly strenuous activity, high-stress events, or coitus, but it can be seen with migraines. However, this cinematic portrayal has little in common with the reality of amnesia. Continuing Education Activity Transient global amnesia (TGA) is acute onset anterograde amnesia that is temporary and usually occurs in middle-aged and older individuals. They are essentially starting over, but they, for the most part, are fully equipped mentally to do so. Characters often appear with no identity and no memories of the past. Although TGA has a strikingly stereotypical presentation, it can be challenging to distinguish from other causes of acute-onset amnesia, including. Amnesia is a popular theme for many movies and television shows. 53.5%, p < 0.01), depression (isolated vs. Transient global amnesia (TGA) is the most common cause of acute-onset amnesia, and is characterised by a profound anterograde and retrograde amnesia that typically lasts for up to 24 hours. Risk factors associated with recurrence were head injury (isolated vs. Eighty-four patients had possible comorbidities or risk factors for TGA, though no single risk factor was ubiquitous. Fifteen of 93 (16%) patients experienced a recurrence of TGA.Īmong precipitating events, physical activities inducing Valsalva-like manoeuvres were most common, followed by emotional stress. Patients were followed from 2004 to 2016. We evaluated clinical history, family history and magnetic resonance diffusion-weighted imaging (DWI) studies of 93 prospective patients with TGA. ![]() We attempted to determine risk factors for TGA, as well as prognostic factors that may cause recurrence. Aetiology of transient global amnesia (TGA) remains uncertain, though many have been proposed, including ischaemic, migrainous or epileptic pathologies.
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